Single-nucleus transcriptomics reveals adrenergic and STAT3 signalling in paradoxical low-flow low-gradient-specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment

Cardiovasc Res. 2024 Nov 5;120(13):1505-1507. doi: 10.1093/cvr/cvae137.

Xingbo Xu^{1

2}, Xiaoying Tan^{2

3}, Baolong Cui^{1

2}, Niels B Paul^{1

4}, Manar Elkenani^{1

2}, Bo E Beuthner^{1

2}, Weichao Li^{1

2}, Belal A Mohamed^{1

2}, Moritz Schnelle^{2

5}, Miriam Puls^{1

2}, Elisabeth M Zeisberg^{1

2}, Michael Zeisberg³, Tim Beißbarth⁴, Karl Toischer^{1

2}, Gerd Hasenfuß^{1

2}

¹ Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
² German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany.
³ Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
⁴ Department of Medical Bioinformatics, University Medical Center Göttingen, Goldschmidtstraße 1, 37077 Göttingen, Germany.
⁵ Department of Clinical Chemistry, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

No abstract available

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