Introduction: Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance to benign lesions like radial scar and complex sclerosing lesions.
Case presentation: We present a case of a 53-year-old woman with a subareolar mass initially thought to be a fibroepithelial neoplasm on core biopsy. Subsequent wide excision revealed LGASC with oestrogen receptor expression (weak to moderate intensity, 40% of tumour cells).
Conclusion: These findings, rarely reported, highlight the difficulty of diagnosing LGASC on small tissue samples.
Keywords: Breast cancer; Core biopsy; ER positivity; Frozen section; Low-grade adenosquamous carcinoma.
© 2024 S. Karger AG, Basel.