Current Mycoplasma pneumoniae outbreak: Don't forget its role in Bickerstaff encephalitis

Thomas Lacampagne; Vivien Guillotin; Olivia Peuchant; Antoine Belloir; Igor Sibon; Cécile Bébéar; Charles Cazanave

doi:10.1016/j.diagmicrobio.2024.116418

Current Mycoplasma pneumoniae outbreak: Don't forget its role in Bickerstaff encephalitis

Diagn Microbiol Infect Dis. 2024 Sep;110(1):116418. doi: 10.1016/j.diagmicrobio.2024.116418. Epub 2024 Jun 28.

Authors

Thomas Lacampagne¹, Vivien Guillotin¹, Olivia Peuchant², Antoine Belloir³, Igor Sibon³, Cécile Bébéar⁴, Charles Cazanave⁵

Affiliations

¹ CHU Bordeaux, Intensive Care Unit, Bordeaux, France.
² CHU Bordeaux, Bacteriology Department, National Reference Centre for Bacterial Sexually Transmitted Infections, Bordeaux, France; University Bordeaux, CNRS, UMR 5234, Fundamental Microbiology and Pathogenicity, Bordeaux, France. Electronic address: [email protected].
³ CHU Bordeaux, Neurology Department, Bordeaux, France.
⁴ CHU Bordeaux, Bacteriology Department, National Reference Centre for Bacterial Sexually Transmitted Infections, Bordeaux, France; University Bordeaux, CNRS, UMR 5234, Fundamental Microbiology and Pathogenicity, Bordeaux, France.
⁵ CHU Bordeaux, Bacteriology Department, National Reference Centre for Bacterial Sexually Transmitted Infections, Bordeaux, France; University Bordeaux, CNRS, UMR 5234, Fundamental Microbiology and Pathogenicity, Bordeaux, France; CHU Bordeaux, Infectious and Tropical Diseases Department, Bordeaux, France.

PMID: 38954862
DOI: 10.1016/j.diagmicrobio.2024.116418

Abstract

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in children and young adults. It is responsible of a broad array of extrapulmonary manifestations, the most severe affecting the central nervous system. We report a challenging diagnosis of macrolide-resistant M. pneumoniae-induced Bickerstaff encephalitis in a 16-year-old man.

Keywords: Bickerstaff encephalitis; Immunomodulators; Macrolide resistance; Mycoplasma pneumoniae.

Publication types

Case Reports

MeSH terms

Adolescent
Anti-Bacterial Agents / therapeutic use
Community-Acquired Infections / diagnosis
Community-Acquired Infections / epidemiology
Community-Acquired Infections / microbiology
Disease Outbreaks
Drug Resistance, Bacterial
Encephalitis* / diagnosis
Encephalitis* / microbiology
Humans
Macrolides / therapeutic use
Male
Mycoplasma pneumoniae* / genetics
Mycoplasma pneumoniae* / isolation & purification
Pneumonia, Mycoplasma* / diagnosis
Pneumonia, Mycoplasma* / drug therapy
Pneumonia, Mycoplasma* / epidemiology
Pneumonia, Mycoplasma* / microbiology

Substances

Anti-Bacterial Agents
Macrolides