Abstract
人乳头状瘤病毒（HPV）相关性多表型鼻腔鼻窦癌（HPV-related multiphenoytpic sinonasal carcinoma，HMSC）是第5版WHO头颈部肿瘤分类新纳入的独特罕见病种，是一种与HPV相关的双相型上皮性肿瘤。病理学上需要与组织形态相似的腺样囊性癌相鉴别。患者女，82岁。因右侧鼻塞进行性加重入院。CT平扫示右侧鼻腔内团片状软组织肿块影。电子鼻内镜见右侧中鼻道被肿物充填。光镜下，组织形态与腺样囊性癌相似，局灶呈鳞状上皮分化，伴角化，可见多灶坏死，核分裂象易见。免疫组织化学染色显示p16、SOX10弥漫强阳性。聚合酶链反应-反向点杂交法证实高危型HPV33型感染，HPV E6E7 mRNA原位杂交结果阳性，MYB/NFIB融合基因阴性。.
MeSH terms
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Aged, 80 and over
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Carcinoma, Adenoid Cystic / pathology
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Carcinoma, Adenoid Cystic / virology
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Cyclin-Dependent Kinase Inhibitor p16 / metabolism
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Female
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Humans
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Papillomaviridae / genetics
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Papillomavirus Infections* / virology
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Paranasal Sinus Neoplasms* / genetics
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Paranasal Sinus Neoplasms* / pathology
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Paranasal Sinus Neoplasms* / virology
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SOXE Transcription Factors
Substances
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Cyclin-Dependent Kinase Inhibitor p16
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SOX10 protein, human
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SOXE Transcription Factors