Sensitive subcellular scale and real-time detection of hydrogen peroxide by a W-doped Pt microelectrode

Chem Commun (Camb). 2024 Jul 18;60(59):7630-7633. doi: 10.1039/d4cc02835j.

Abstract

A W-doped Pt modified graphene oxide (Pt-W-GO) electrochemical microelectrode was developed to detect hydrogen peroxide (H2O2) in real time at a subcellular scale. Interestingly, results showed that the concentration of H2O2 in the nucleus of HeLa cells was 2.68 times and 0.51 times that in the extracellular membrane and cytoplasm, respectively.

MeSH terms

  • Electrochemical Techniques*
  • Graphite* / chemistry
  • HeLa Cells
  • Humans
  • Hydrogen Peroxide* / analysis
  • Hydrogen Peroxide* / chemistry
  • Microelectrodes*
  • Platinum* / chemistry

Substances

  • Hydrogen Peroxide
  • Platinum
  • Graphite
  • graphene oxide