Granulation-embedded autologous skin grafting improves healing chronic wounds at high altitudes: a pilot study

Wound Manag Prev. 2024 Jun;70(2). doi: 10.25270/wmp.23028.

Abstract

Background: The management of chronic wounds presents a challenge for surgeons. In this pilot study, the authors established a novel auto-grafting approach for chronic wounds and evaluated its efficacy.

Purpose: The objective of this pilot study was to observe the clinical efficacy of granulation-embedded skin grafting for the treatment of chronic wounds at high altitudes.

Methods: The data of 45 patients with chronic wounds were obtained from the medical records of the Yushu People's Hospital. Patients were divided into stamp skin-grafting and granulation-embedded skin-grafting groups. Skin graft survival rate, wound coverage rate, and wound-healing time were observed and recorded. The length of hospital stay and 1% total body surface area (TBSA) treatment cost were compared.

Results: Significant differences were noted in skin graft survival rate (94% ± 3% vs 86% ± 3%, P < .01), wound coverage rate on postoperative day 7 (61% ± 16% vs 54% ± 18%, P < .01), and wound-healing times (23 ± 2.52 days vs 31 ± 3.61 days, P < .05). The length of hospital stay and 1% TBSA treatment cost were significantly reduced in the granulation-embedded skin grafting group (P < .05).

Conclusions: Granulation-embedded skin grafting can improve the healing of chronic wounds at high altitudes. These findings provide a new approach to the clinical treatment of chronic wounds.

MeSH terms

  • Adult
  • Aged
  • Altitude*
  • Chronic Disease
  • Female
  • Graft Survival / physiology
  • Granulation Tissue / physiopathology
  • Humans
  • Length of Stay / statistics & numerical data
  • Male
  • Middle Aged
  • Pilot Projects
  • Skin Transplantation* / methods
  • Skin Transplantation* / statistics & numerical data
  • Transplantation, Autologous* / methods
  • Transplantation, Autologous* / statistics & numerical data
  • Wound Healing* / physiology
  • Wounds and Injuries / physiopathology
  • Wounds and Injuries / surgery
  • Wounds and Injuries / therapy