Ductal Carcinoma In Situ

Brittany L Bychkovsky; Sara Myers; Laura E G Warren; Pietro De Placido; Heather A Parsons

doi:10.1016/j.hoc.2024.05.014

Ductal Carcinoma In Situ

Hematol Oncol Clin North Am. 2024 Aug;38(4):831-849. doi: 10.1016/j.hoc.2024.05.014.

Authors

Brittany L Bychkovsky¹, Sara Myers², Laura E G Warren³, Pietro De Placido⁴, Heather A Parsons⁵

Affiliations

¹ Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
² Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.
³ Harvard Medical School, Boston, MA, USA; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
⁴ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
⁵ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: [email protected].

PMID: 38960507
DOI: 10.1016/j.hoc.2024.05.014

Abstract

In breast cancer (BC) pathogenesis models, normal cells acquire somatic mutations and there is a stepwise progression from high-risk lesions and ductal carcinoma in situ to invasive cancer. The precancer biology of mammary tissue warrants better characterization to understand how different BC subtypes emerge. Primary methods for BC prevention or risk reduction include lifestyle changes, surgery, and chemoprevention. Surgical intervention for BC prevention involves risk-reducing prophylactic mastectomy, typically performed either synchronously with the treatment of a primary tumor or as a bilateral procedure in high-risk women. Chemoprevention with endocrine therapy carries adherence-limiting toxicity.

Keywords: Breast cancer detection; Breast cancer precursor lesions; DCIS; Ductal carcinoma in situ.

Publication types

Review

MeSH terms

Breast Neoplasms* / genetics
Breast Neoplasms* / pathology
Breast Neoplasms* / therapy
Carcinoma, Intraductal, Noninfiltrating* / pathology
Carcinoma, Intraductal, Noninfiltrating* / therapy
Female
Humans