Breaking boundaries: Bacteria act as architects of host T cell modulators using bile acids

Science. 2024 Jul 5;385(6704):37. doi: 10.1126/science.adq2341. Epub 2024 Jul 4.

Author

Lina Yao^{1

2}

Affiliations

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
² Genentech, Inc., South San Francisco, CA, USA.

PMID: 38963847
DOI: 10.1126/science.adq2341

Abstract

Bacteria act as architects of host T cell modulators using bile acids.

MeSH terms

Animals
Bacteria* / genetics
Bacteria* / isolation & purification
Bacteria* / metabolism
Bile Acids and Salts* / metabolism
Feces / microbiology
Gastrointestinal Microbiome*
Humans
Immunomodulation*
Mice
Receptors, Cytoplasmic and Nuclear
Receptors, G-Protein-Coupled / metabolism
T-Lymphocytes* / immunology

Substances

Bile Acids and Salts
farnesoid X-activated receptor
GPBAR1 protein, human
Receptors, Cytoplasmic and Nuclear
Receptors, G-Protein-Coupled