Effects of virtual reality-based robot therapy combined with task-oriented therapy on upper limb function and cerebral cortex activation in patients with stroke

Medicine (Baltimore). 2024 Jul 5;103(27):e38723. doi: 10.1097/MD.0000000000038723.

Abstract

Background: This study aimed to investigate the effects of virtual reality (VR)-based robot therapy combined with task-oriented therapy on cerebral cortex activation and upper limb function in patients with stroke.

Methods: This study included 46 patients with hemiplegia within 1 year of stroke onset. Patients were divided into an experimental group (n = 23) and a control group (n = 23) using a computer randomization program. The experimental group received VR-based robot and task-oriented therapies, whereas the control group received only task-oriented therapy. All participants received interventions for 40 minutes per session, 5 times a week, for 8 weeks. For the pre- and post-evaluation of all participants, the Fugl-Meyer Assessment for the upper extremity, manual function test, motor activity log, and Jebsen-Taylor Hand Function Test were used to evaluate changes in upper limb function and motor-evoked potential amplitudes were measured to compare cerebral cortex activation.

Results: In comparison to the control group, experimental group demonstrated an improvement in the function of the upper limb (P < .01) and activation of the cerebral cortex (P < .01).

Conclusion: The combined intervention of VR-based robot and task-oriented therapies is valuable for improving upper limb function and cerebral cortex activation in patients with stroke.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Cerebral Cortex* / physiopathology
  • Evoked Potentials, Motor / physiology
  • Female
  • Hemiplegia / etiology
  • Hemiplegia / physiopathology
  • Hemiplegia / rehabilitation
  • Hemiplegia / therapy
  • Humans
  • Male
  • Middle Aged
  • Recovery of Function
  • Robotics* / methods
  • Stroke Rehabilitation* / instrumentation
  • Stroke Rehabilitation* / methods
  • Stroke* / complications
  • Stroke* / physiopathology
  • Stroke* / therapy
  • Treatment Outcome
  • Upper Extremity* / physiopathology
  • Virtual Reality*