Two cases of metastatic colorectal cancer with prolonged liver injury following capecitabine combination chemotherapy

BMJ Case Rep. 2024 Jul 5;17(7):e260012. doi: 10.1136/bcr-2024-260012.

Abstract

We present two cases of metastatic colorectal cancer where a liver injury developed while receiving capecitabine. In both cases, the patients were switched from oral capecitabine to a continuous intravenous 5-fluorouracil infusion and were able to continue treatment without a relapse of hepatotoxicity.

Keywords: Chemotherapy; Colon cancer.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic* / administration & dosage
  • Antimetabolites, Antineoplastic* / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Capecitabine* / administration & dosage
  • Capecitabine* / adverse effects
  • Chemical and Drug Induced Liver Injury* / diagnosis
  • Chemical and Drug Induced Liver Injury* / etiology
  • Colorectal Neoplasms* / drug therapy
  • Female
  • Fluorouracil / administration & dosage
  • Fluorouracil / adverse effects
  • Humans
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged

Substances

  • Capecitabine
  • Antimetabolites, Antineoplastic
  • Fluorouracil