Large airway wall vascularity in patients with asthma-COPD overlap: a bronchoscopy study

Surajit Dey; Wenying Lu; Heinrich C Weber; Collin Chia; Prabuddha S Pathinayake; Peter A B Wark; Mathew Suji Eapen; Sukhwinder Singh Sohal

doi:10.1183/23120541.00002-2024

Large airway wall vascularity in patients with asthma-COPD overlap: a bronchoscopy study

ERJ Open Res. 2024 Jul 8;10(4):00002-2024. doi: 10.1183/23120541.00002-2024. eCollection 2024 Jul.

Authors

Surajit Dey¹, Wenying Lu^{1

2}, Heinrich C Weber^{1

3}, Collin Chia^{1

2

4}, Prabuddha S Pathinayake⁵, Peter A B Wark^{5

6}, Mathew Suji Eapen¹, Sukhwinder Singh Sohal^{1

2}

Affiliations

¹ Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia.
² Launceston Respiratory and Sleep Centre, Launceston, Australia.
³ Department of Respiratory Medicine, Tasmanian Health Services, North-West Hospital, Burnie, Australia.
⁴ Department of Respiratory Medicine, Launceston General Hospital, Launceston, Australia.
⁵ Immune Health Program, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia.
⁶ Department of Respiratory Medicine, Monash University, Melbourne, Australia.

Abstract

Large airway wall lamina propria in patients with asthma-COPD overlap is hypovascular with an increase in reticular basement membrane neoangiogenesis, reflecting smoking-related COPD-like pathology and potential epithelial-to-mesenchymal transition https://bit.ly/49DeoFX.