Wireless asymmetric umpolung electrosynthesis

Chem Commun (Camb). 2024 Sep 12;60(74):10120-10123. doi: 10.1039/d4cc02406k.

Abstract

Electroorganic synthesis has become an exciting tool for the asymmetric conversion of pro-chiral compounds. Herein, we introduced a wireless methodology based on bipolar electrochemistry in synergy with the enantioselective capabilities of inherently chiral oligomers to induce an umpolung chirality transfer. This was exemplified by the electro-conversion of a racemic mixture of lansoprazole to an enantio-enriched solution of a single antipode.