Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination

Veronica Lise; Ines Malenica; Rahul Roychoudhuri; Enrico Lugli

doi:10.1016/j.ccell.2024.06.010

Immune cell triads reprogram exhausted CD8⁺ T cells for effective tumor elimination

Cancer Cell. 2024 Jul 8;42(7):1152-1154. doi: 10.1016/j.ccell.2024.06.010.

Authors

Veronica Lise¹, Ines Malenica¹, Rahul Roychoudhuri², Enrico Lugli³

Affiliations

¹ IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
² Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QP Cambridge, UK.
³ IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy. Electronic address: [email protected].

PMID: 38981434
DOI: 10.1016/j.ccell.2024.06.010

Abstract

In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4⁺ and CD8⁺ T cells. This interaction reprograms tumor-specific CD8⁺ T cells to exert potent effector functions and eradicate established solid tumors.

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MeSH terms

Animals
Antigen-Presenting Cells / immunology
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes* / immunology
Humans
Immunotherapy / methods
Mice
Neoplasms* / immunology
Neoplasms* / therapy