A gain of function mutation in PITX2c gene linked to atrial fibrillation alters mitochondrial function and membrane excitability

Vascul Pharmacol. 2024 Jun:155:107298. doi: 10.1016/j.vph.2024.107298.
No abstract available

MeSH terms

  • Animals
  • Atrial Fibrillation* / diagnosis
  • Atrial Fibrillation* / genetics
  • Atrial Fibrillation* / physiopathology
  • Gain of Function Mutation*
  • Genetic Predisposition to Disease
  • Homeobox Protein PITX2*
  • Homeodomain Proteins* / genetics
  • Humans
  • Membrane Potential, Mitochondrial / genetics
  • Mitochondria, Heart / genetics
  • Mitochondria, Heart / metabolism
  • Mitochondria, Heart / pathology
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / pathology
  • Phenotype
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • Homeobox Protein PITX2
  • Transcription Factors
  • Homeodomain Proteins