Human cardiac microtissues capture aberrant RNA splicing in doxorubicin-induced cardiotoxicity

Vascul Pharmacol. 2024 Jun:155:107339. doi: 10.1016/j.vph.2024.107339.

Authors

Daniele Ottaviani¹, Caterina Millino², Federica D'Ettorre¹, Milena Bellin³

Affiliations

¹ Department of Biology, University of Padova, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.
² Department of Biology, University of Padova, 35131 Padova, Italy.
³ Department of Biology, University of Padova, 35131 Padova, Italy; Veneto Institute of Molecular Medicine, 35129 Padova, Italy; Department of Anatomy and Embryology, Leiden University Medical Center, 2333ZC Leiden, The Netherlands.

PMID: 38985617
DOI: 10.1016/j.vph.2024.107339

No abstract available

Publication types

Letter

MeSH terms

Alternative Splicing / drug effects
Antibiotics, Antineoplastic* / adverse effects
Cardiotoxicity*
Doxorubicin* / adverse effects
Humans
Myocytes, Cardiac* / drug effects
Myocytes, Cardiac* / metabolism
Myocytes, Cardiac* / pathology
RNA Splicing / drug effects

Substances

Doxorubicin
Antibiotics, Antineoplastic