Unraveling links between aging, circadian rhythm and cancer: Insights from evidence-based analysis

Dechao Feng; Yuhan Xiao; Jie Wang; Ruicheng Wu; Zhouting Tuo; Koo Han Yoo; Wuran Wei; Dilinaer Wusiman; Zhipeng Wang; Dengxiong Li; Yubo Yang; William C Cho; Mang Ke

doi:10.21147/j.issn.1000-9604.2024.03.09

Unraveling links between aging, circadian rhythm and cancer: Insights from evidence-based analysis

Chin J Cancer Res. 2024 Jun 30;36(3):341-350. doi: 10.21147/j.issn.1000-9604.2024.03.09.

Authors

Dechao Feng^{1

2

3}, Yuhan Xiao¹, Jie Wang¹, Ruicheng Wu¹, Zhouting Tuo⁴, Koo Han Yoo⁵, Wuran Wei¹, Dilinaer Wusiman^{6

7}, Zhipeng Wang⁸, Dengxiong Li¹, Yubo Yang⁹, William C Cho¹⁰, Mang Ke³

Affiliations

¹ Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
² Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK.
³ Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou 317000, China.
⁴ Department of Urology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
⁵ Department of Urology, Kyung Hee University, Seoul 130-701, South Korea.
⁶ Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA.
⁷ Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
⁸ Department of Urology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
⁹ Department of Urology, Three Gorges Hospital, Chongqing University, Chongqing 404000, China.
¹⁰ Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China.

PMID: 38988484
PMCID: PMC11230883
DOI: 10.21147/j.issn.1000-9604.2024.03.09

Abstract

Aging and circadian rhythms have been connected for decades, but their molecular interaction has remained unknown, especially for cancers. In this situation, we summarized the current research actuality and problems in this field using the bibliometric analysis. Publications in the PubMed and Web of Science databases were retrieved. Overall, there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of cancer. Researchers from USA, Germany, Italy, China and England have greater studies than others. Top three publication institutions are University of California System, UDICE-French Research Universities and University of Texas System. Current research hotspots include oxidative stress, breast cancer, melatonin, cell cycle, calorie restriction, prostate cancer and NF-KB. In conclusion, results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in cancer. These established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.

Keywords: Aging; bibliometric analysis; circadian rhythm; human cancer; oxidative stress.