Dermatological Conundrum: Puzzling Pigmentation in Vitamin B12 Deficiency and Addison's Disease

J Assoc Physicians India. 2024 Jul;72(7):102-105. doi: 10.59556/japi.72.0570.

Abstract

We report a case series of two patients who had similar skin pigmentation but were caused by vitamin B12 deficiency and Addison's disease. We further discuss the pathophysiology of skin hyperpigmentation in both of these disorders and the response to treatment. Our case report highlights the importance of the identification of simple bedside clinical signs to diagnose reversible causes of skin pigmentation.

Publication types

  • Case Reports

MeSH terms

  • Addison Disease* / complications
  • Addison Disease* / diagnosis
  • Addison Disease* / etiology
  • Adult
  • Female
  • Humans
  • Hyperpigmentation* / diagnosis
  • Hyperpigmentation* / etiology
  • Male
  • Middle Aged
  • Vitamin B 12
  • Vitamin B 12 Deficiency* / complications
  • Vitamin B 12 Deficiency* / diagnosis

Substances

  • Vitamin B 12