Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Front Immunol. 2024 Jun 27:15:1440309. doi: 10.3389/fimmu.2024.1440309. eCollection 2024.

Abstract

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

Keywords: corneal injury; eye diseases; ferroptosis; metabolic pathway; therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Death
  • Eye Diseases* / metabolism
  • Eye Diseases* / pathology
  • Ferroptosis*
  • Humans
  • Iron / metabolism
  • Lipid Peroxidation
  • Reactive Oxygen Species / metabolism
  • Signal Transduction

Substances

  • Reactive Oxygen Species
  • Iron

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.