Reduction hits the sweet spot: A revised biosynthesis of dolichol

Sarah E O'Connor

doi:10.1016/j.cell.2024.05.006

Reduction hits the sweet spot: A revised biosynthesis of dolichol

Cell. 2024 Jul 11;187(14):3502-3503. doi: 10.1016/j.cell.2024.05.006.

Author

Sarah E O'Connor¹

Affiliation

¹ Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany. Electronic address: [email protected].

PMID: 38996484
DOI: 10.1016/j.cell.2024.05.006

Abstract

Dolichol is a lipid that is involved in protein glycosylation, a process that is essential for all eukaryotic life. In this issue of Cell, Wilson and coworkers¹ report how a rare human genetic disorder led to the discovery of dolichol biosynthesis.

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MeSH terms

Dolichols* / biosynthesis
Dolichols* / metabolism
Glycosylation
Humans

Substances

Dolichols