Exploring the natural efficacy of spirulina powder for combating obesity, diabetes, and inflammation

J Sci Food Agric. 2024 Dec;104(15):9128-9136. doi: 10.1002/jsfa.13734. Epub 2024 Jul 12.

Abstract

Background: An increasing incidence of metabolic disorders emphasizes the need to explore natural treatments. Spirulina, a microalga with a rich nutrient profile, offers a promising solution for obesity, diabetes, and inflammation. This study provides a meticulous analysis of spirulina powder, evaluating its physicochemical attributes and technofunctional properties through the use of advanced analytical techniques.

Results: Spirulina powder demonstrated strong flowability, substantial water and oil absorption capacity, and moderate foaming characteristics. The ethanolic extract of spirulina was found to be a repository of phenolic (6.93 mg GAE/g) and flavonoid (7.17 mg QE/g) compounds, manifesting considerable antioxidant activity with a 58.49 g kg-1 inhibition of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The extract also exhibited pronounced inhibitory effects on lipase and amylase enzymes, with inhibition percentages of 72.05 g kg-1 and 70.28 g kg-1, respectively, and displayed a glucose retention capacity of 1.28 mg dL-1 (68.52 g kg-1) in a dialysis membrane assay. These results suggest its efficacy in modulating obesity and glycemic control. The powder also showed a potent anti-inflammatory response by mitigating protein denaturation.

Conclusion: Spirulina powder is a potent natural agent with multiple health benefits, meriting its incorporation into functional foods. It could be suitable for application in the food industry, offering a natural strategy to combat metabolic diseases. This research adds to the scientific literature on spirulina, paving the way for future research into its utilization. © 2024 The Author(s). Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Keywords: FTIR; GC–MS; anti‐inflammatory; glucose; lipase; spirulina.

MeSH terms

  • Amylases / antagonists & inhibitors
  • Amylases / metabolism
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants* / chemistry
  • Antioxidants* / pharmacology
  • Diabetes Mellitus / drug therapy
  • Humans
  • Inflammation* / drug therapy
  • Inflammation* / prevention & control
  • Lipase / antagonists & inhibitors
  • Lipase / metabolism
  • Obesity* / drug therapy
  • Obesity* / metabolism
  • Powders* / chemistry
  • Spirulina* / chemistry

Substances

  • Antioxidants
  • Powders
  • Lipase
  • Amylases
  • Anti-Inflammatory Agents