COVID-19 vaccination initiation and completion in a multicenter cohort study of insured US transgender and cisgender adults

Ann Epidemiol. 2024 Sep:97:11-15. doi: 10.1016/j.annepidem.2024.07.042. Epub 2024 Jul 14.

Abstract

Purpose: Transgender and gender-diverse (TGD) people may have been disproportionately impacted by the COVID-19 pandemic, yet little is known about vaccination status in this population. This multicenter cohort study of insured adults examined the rates of COVID-19 vaccine initiation and completion in TGD persons compared to matched cisgender persons.

Methods: A cohort of TGD persons and matched cisgender persons enrolled in Kaiser Permanente health plans in Northern and Southern California between 12/1/2020 and 7/31/2021 were analyzed. COVID-19 vaccination initiation and completion rates were compared across groups using Cox regression models.

Results: Among transmasculine persons, the HR (95 % CI) estimates for COVID-19 vaccination initiation and completion were, respectively, 1.35 (1.30-1.40) and 1.78 (1.71-1.85) compared with cisgender women and 1.34 (1.29-1.40) and 1.81 (1.73-1.88) compared with cisgender men. Among transfeminine persons, the corresponding HRs (95 % CIs) for vaccination initiation and completion were 1.35 (1.30-1.40) and 1.78 (1.71-1.85) compared with cisgender women and 1.34 (1.29-1.40) and 1.81 (1.73-1.88) compared with cisgender men.

Conclusion: Findings from this cohort of insured adults demonstrated that TGD persons initiated and completed COVID-19 vaccination at higher rates compared to matched cisgender persons. Further work is needed to understand vaccination rates and determinants in the broader TGD populations.

Keywords: COVID-19 vaccines; Health services for transgender transgenderpersons; Transgender persons; health equity.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • COVID-19 Vaccines* / administration & dosage
  • COVID-19* / epidemiology
  • COVID-19* / prevention & control
  • California / epidemiology
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • SARS-CoV-2*
  • Transgender Persons* / statistics & numerical data
  • United States
  • Vaccination Coverage / statistics & numerical data
  • Vaccination* / statistics & numerical data
  • Young Adult

Substances

  • COVID-19 Vaccines