Molecular Editing of Pyrroles to Benzenes/Naphthalenes by N₂O Deletion

Molecular editing promises to facilitate the rapid diversification of complex molecular architectures by rapidly and conveniently altering core frameworks. This approach has the potential to accelerate both drug discovery and total synthesis. In this study, we present a novel protocol for the molecular editing of pyrroles. Initially, N‐Boc pyrroles and alkynes are converted into N‐bridged compounds through a Diels–Alder reaction. These compounds then undergo deprotection of the Boc group, nitrosylation, and cheletropic N₂O extrusion to yield benzene or naphthalene products. By using benzyne as a substrate, this method can be conceptually viewed as a fusion of skeletal editing of the pyrrole ring and site‐selective peripheral editing of the benzene ring. Furthermore, this proof‐of‐concept protocol has demonstrated its potential to transform the (hetero)arene motif from commercially available drugs, offering the possibility of generating new biologically active compounds.