Assessment of Ki-67 and mitoses in pituitary neuroendocrine tumours-Consistency counts

Brain Pathol. 2025 Jan;35(1):e13285. doi: 10.1111/bpa.13285. Epub 2024 Jul 15.

Abstract

Pituitary neuroendocrine tumour Ki-67 proliferation index varies according to the number of tumour cells assessed. Consistent Ki-67 scoring approaches and re-evaluation of the recommended Ki-67 3% cut-off are required to clarify controversies in pituitary neuroendocrine tumour Ki-67 proliferation index assessment.

Keywords: Ki‐67; digital pathology; mitotic index; neuropathology; pituitary adenoma; pituitary neuroendocrine tumour.

Publication types

  • Letter

MeSH terms

  • Cell Proliferation
  • Humans
  • Ki-67 Antigen* / metabolism
  • Mitotic Index
  • Neuroendocrine Tumors* / diagnosis
  • Neuroendocrine Tumors* / metabolism
  • Neuroendocrine Tumors* / pathology
  • Pituitary Neoplasms* / metabolism
  • Pituitary Neoplasms* / pathology

Substances

  • Ki-67 Antigen