Emerging platelet-based drug delivery systems

Mengkun Fang; Rui Liu; Yile Fang; Dagan Zhang; Bin Kong

doi:10.1016/j.biopha.2024.117131

Emerging platelet-based drug delivery systems

Biomed Pharmacother. 2024 Aug:177:117131. doi: 10.1016/j.biopha.2024.117131. Epub 2024 Jul 15.

Authors

Mengkun Fang¹, Rui Liu¹, Yile Fang², Dagan Zhang³, Bin Kong⁴

Affiliations

¹ Department of haematology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210002, China.
² Department of haematology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210002, China. Electronic address: [email protected].
³ Department of haematology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210002, China. Electronic address: [email protected].
⁴ Department of haematology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210002, China; Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518055, China; Department of Neurosurgery, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, China. Electronic address: [email protected].

PMID: 39013224
DOI: 10.1016/j.biopha.2024.117131

Abstract

Drug delivery systems are becoming increasingly utilized; however, a major challenge in this field is the insufficient target of tissues or cells. Although efforts with engineered nanoparticles have shown some success, issues with targeting, toxicity and immunogenicity persist. Conversely, living cells can be used as drug-delivery vehicles because they typically have innate targeting mechanisms and minimal adverse effects. As active participants in hemostasis, inflammation, and tumors, platelets have shown great potential in drug delivery. This review highlights platelet-based drug delivery systems, including platelet membrane engineering, platelet membrane coating, platelet cytoplasmic drug loading, genetic engineering, and synthetic/artificial platelets for different applications.

Keywords: Drug delivery system; Genetic engineering; Membrane; Platelet; Tumor.

Publication types

Review

MeSH terms

Animals
Blood Platelets* / drug effects
Blood Platelets* / metabolism
Drug Carriers / chemistry
Drug Delivery Systems* / methods
Genetic Engineering / methods
Humans
Nanoparticles

Substances

Drug Carriers