Prenatal diagnostic and intervention considerations in congenital diaphragmatic hernia

Semin Pediatr Surg. 2024 Aug;33(4):151436. doi: 10.1016/j.sempedsurg.2024.151436. Epub 2024 Jul 2.

Abstract

Congenital diaphragmatic hernia (CDH) is a life-threatening birth defect with significant morbidity and mortality. The prenatal management of a pregnancy with a fetus affected with CDH is complex and requires a multi-disciplinary team approach. An improved understanding of prenatal diagnosis and management is essential to developing strategies to optimize outcomes for these patients. In this review, we explore the current knowledge on diagnosis, severity stratification, prognostic prediction, and indications for fetal intervention in the fetus with CDH.

Keywords: Congenital diaphragmatic hernia; Fetoscopic tracheal occlusion; Prenatal diagnosis; Pulmonary hypertension; Pulmonary hypoplasia.

Publication types

  • Review

MeSH terms

  • Female
  • Hernias, Diaphragmatic, Congenital* / diagnosis
  • Hernias, Diaphragmatic, Congenital* / surgery
  • Hernias, Diaphragmatic, Congenital* / therapy
  • Humans
  • Pregnancy
  • Prenatal Diagnosis* / methods
  • Prognosis
  • Ultrasonography, Prenatal