No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study

Valentino Conter; Maria Grazia Valsecchi; Paola De Lorenzo; Virginie Gandemer; Mats Heyman; Vaskar Saha; Paulina Diaz; Chi-Kong Li; Andishe Attarbaschi; Gabriele Escherich; Jan Stary; Martin Schrappe; Rob Pieters; Gunnar Cario; Andrea Biondi

doi:10.3324/haematol.2024.285253

No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study

Haematologica. 2024 Nov 1;109(11):3766-3770. doi: 10.3324/haematol.2024.285253.

Authors

Affiliations

¹ Pediatrics and Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza.
² Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca.
³ Department of Pediatric Hemato-Oncology, University Hospital of Rennes, Rennes.
⁴ Department of Paediatric Oncology, Karolinska University Hospital and Department of Women's and Children's Health, Karolinska Institutet, Stockholm.
⁵ Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Tata Translational Cancer Research Centre, Tata Medical Center, Kolkata.
⁶ Chilean National Pediatric Oncology Group, Santiago, Chile; Hospital Dr. Gustavo Fricke, Vina del Mar, Chile.
⁷ The Chinese University of Hong Kong, Hong Kong Children's Hospital.
⁸ Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria; St. Anna Children's Cancer Research Institute, Vienna.
⁹ University Medical Centre Hamburg-Eppendorf, Clinic of Paediatric Haematology and Oncology, Hamburg.
¹⁰ Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
¹¹ University Medical Center Schleswig-Holstein, Pediatrics, Campus Kiel, Kiel.
¹² Princess Maxima Center for Pediatric Oncology, Utrecht.
¹³ Pediatrics and Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca. [email protected].

No abstract available

Grants and funding

Funding: The work was partially supported by the grant PRIN 2022SYXEHJ (principal investigator MGV). Projet Hospitalier de Recherche Clinique-Cancer and Novartis France (to VG).