From detection to disappearance: A tale of a nodule

Spindle cell lesions span from benign to aggressively malignant, the most concerning being the carcinoma, sarcoma, and melanoma species. While spindle cell carcinoma is the most common spindle cell lesion found along the upper aerodigestive tract (UADT), it only accounts for <0.5 % of pulmonary malignancies [1,2]. We present an adult male admitted for chest pain, who was found to have a malignant left upper lobe (LUL) spindle cell neoplasm. Three pathology departments preformed immunohistochemical analysis on various tissue specimens, searching for a speciated diagnosis, highlighting the importance of advanced immunostains for the diagnosis and subsequent treatment of these difficult lesions.