Effect of DNA methylation and AUDIT-C polygenic scores on alcohol use disorder comorbidity in psychoses: No evidence of epigenetic basis of polygenic risk

Schizophr Res. 2024 Sep:271:138-141. doi: 10.1016/j.schres.2024.06.035. Epub 2024 Jul 17.

Authors

Nzaar Al-Chalabi¹, George Nader¹, Corinne Fischer², Ariel Graff¹, Philip Gerretsen¹, Vincenzo De Luca³

Affiliations

¹ Centre for Addiction & Mental Health (CAMH), Toronto, Canada.
² St Michael's Hospital, Toronto, Canada.
³ Centre for Addiction & Mental Health (CAMH), Toronto, Canada; St Michael's Hospital, Toronto, Canada. Electronic address: [email protected].

PMID: 39024962
DOI: 10.1016/j.schres.2024.06.035

No abstract available

Keywords: Alcohol use disorder; DNA methylation; EWAS; Polygenic risk scores; Schizophrenia.

Publication types

Letter

MeSH terms

Adult
Alcoholism / genetics
Comorbidity*
DNA Methylation*
Epigenesis, Genetic
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Multifactorial Inheritance*
Psychotic Disorders* / genetics