Regulation of macrophage activation by lactylation in lung disease

Front Immunol. 2024 Jul 4:15:1427739. doi: 10.3389/fimmu.2024.1427739. eCollection 2024.

Abstract

Lactylation is a process where lactate, a cellular metabolism byproduct, is added to proteins, altering their functions. In the realm of macrophage activation, lactylation impacts inflammatory response and immune regulation. Understanding the effects of lactylation on macrophage activation is vital in lung diseases, as abnormal activation and function are pivotal in conditions like pneumonia, pulmonary fibrosis, COPD, and lung cancer. This review explores the concept of lactylation, its regulation of macrophage activation, and recent research progress in lung diseases. It offers new insights into lung disease pathogenesis and potential therapeutic targets.

Keywords: immune regulation; lactylation; lung disease; macrophage; metabolism.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lactic Acid / metabolism
  • Lung Diseases* / immunology
  • Lung Diseases* / metabolism
  • Macrophage Activation* / immunology
  • Macrophages / immunology
  • Macrophages / metabolism

Substances

  • Lactic Acid

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Natural Science Foundation of China (XT, 82270077), the National High-Level Talents Program (XT), R&D Program of Guangzhou National Laboratory, Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01S155), Open Project of State Key Laboratory of Respiratory Disease (SKLRD-OP-202320), Guangzhou Institute of Respiratory Health Open Project (XT).