Abstract
Light and pH dual-responsive ion transporters offer better applicability for cancer due to higher tunability and low cytotoxicity. Herein, we demonstrate the development of pH-responsive β-carboline-based ionophores and photocleavable-linker appended β-carboline-based proionophores to facilitate the controlled transport of Cl- across membranes, leading to apoptotic and autophagic cancer cell death.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Carbolines* / chemistry
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Carbolines* / pharmacology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Hydrogen-Ion Concentration
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Ion Transport / drug effects
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Ionophores / chemistry
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Ionophores / pharmacology
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Light*
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Molecular Structure
Substances
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Carbolines
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Antineoplastic Agents
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Ionophores
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norharman