Transcription factor dependencies identify BAF-dependent cancers

Helen M McRae; Diana C Hargreaves

doi:10.1016/j.ccell.2024.06.013

Transcription factor dependencies identify BAF-dependent cancers

Cancer Cell. 2024 Aug 12;42(8):1326-1328. doi: 10.1016/j.ccell.2024.06.013. Epub 2024 Jul 18.

Authors

Helen M McRae¹, Diana C Hargreaves²

Affiliations

¹ Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
² Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: [email protected].

PMID: 39029465
DOI: 10.1016/j.ccell.2024.06.013

Abstract

In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple myeloma and POU2F3-subtype small cell lung cancer, highlighting potential therapeutic applications for BAF complex inhibitors/degraders.

MeSH terms

Chromatin Assembly and Disassembly
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Humans
Interferon Regulatory Factors / genetics
Interferon Regulatory Factors / metabolism
Lung Neoplasms / genetics
Lung Neoplasms / metabolism
Lung Neoplasms / pathology
Multiple Myeloma / genetics
Multiple Myeloma / metabolism
Multiple Myeloma / pathology
Neoplasms / genetics
Neoplasms / metabolism
Small Cell Lung Carcinoma / genetics
Small Cell Lung Carcinoma / metabolism
Small Cell Lung Carcinoma / pathology
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Transcription Factors
Interferon Regulatory Factors
interferon regulatory factor-4
DNA-Binding Proteins