Disparities in COVID-19-Related Mortality Among Older Adults With Alzheimer's Disease and Related Dementias: Variations Over Time

J Appl Gerontol. 2025 Jan;44(1):11-17. doi: 10.1177/07334648241264908. Epub 2024 Jul 20.

Abstract

Older adults with Alzheimer's disease and related dementias (ADRD) had a high risk of COVID-19-related mortality. Racial and ethnic minorities were disproportionally impacted by the pandemic. The variations in disparities, including racial and ethnic disparities and disparities across communities, in COVID-19-related mortality across the different stages of the COVID-19 pandemic among the ADRD population are unknown. This observational study estimated linear probability models for community-dwelling older adults with ADRD who were diagnosed with COVID-19 in 2020 and 2021 using multiple national data (e.g., Medicare data), accounting for individual and community characteristics. Disparities in 30-day mortality were compared between 2020 and 2021. The socioeconomic disparity in COVID-19-related mortality across communities became insignificant during the later stage of the pandemic, ethnic differences in COVID-19-related mortality decreased but persisted, and racial disparity remained largely unchanged. The study provides insights into interventions to mitigate lingering disparities in health outcomes among the vulnerable population.

Keywords: COVID-19; older adults with ADRD; racial/ethnic differences; socioeconomic status.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease* / ethnology
  • Alzheimer Disease* / mortality
  • COVID-19* / ethnology
  • COVID-19* / mortality
  • Dementia / ethnology
  • Dementia / mortality
  • Ethnic and Racial Minorities / statistics & numerical data
  • Female
  • Health Status Disparities*
  • Humans
  • Male
  • SARS-CoV-2
  • Socioeconomic Factors
  • United States / epidemiology