Metformin reduces the risk of poor treatment outcomes among individuals with rifampicin-resistant tuberculosis and type-2 diabetes mellitus

medRxiv [Preprint]. 2024 Jul 14:2024.07.12.24310348. doi: 10.1101/2024.07.12.24310348.

Abstract

We conducted a retrospective cohort study among individuals with rifampicin-resistant tuberculosis and diabetes to determine the association between metformin use and tuberculosis treatment outcomes. We found that individuals with metformin use had a significantly lower risk of poor tuberculosis treatment outcomes (adjusted RR=0.25, 95%CI 0.06 - 0.95) compared to those without.

Keywords: TB treatment outcomes; diabetes; metformin; post-TB mortality; rifampicin-resistant TB; sputum culture conversion.

Publication types

  • Preprint