The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 10 polyol phosphates. Some of the possible functions in cosmetics that are reported for this ingredient group are chelating agents, oral care agents, and skin conditioning agents. The Panel reviewed relevant data relating to the safety of these ingredients under the intended conditions of use in cosmetic formulations, and concluded that Sodium Phytate, Phytic Acid, Phytin, and Trisodium Inositol Triphosphate are safe in cosmetics in the present practices of use and concentration described in the safety assessment. The Panel also concluded that the data are insufficient to determine the safety of the following 6 ingredients as used in cosmetics: Disodium Glucose Phosphate, Manganese Fructose Diphosphate, Sodium Mannose Phosphate, Trisodium Fructose Diphosphate, Xylityl Phosphate, and Zinc Fructose Diphosphate.
Keywords: Cosmetic Ingredient; Cosmetic Ingredient Review; Disodium Glucose Phosphate; Expert Panel for Cosmetic Ingredient Safety; Manganese Fructose Diphosphate; Phytic Acid; Phytin; Polyol Phosphates; Safety; Sodium Mannose Phosphate; Sodium Phytate; Trisodium Fructose Diphosphate; Trisodium Inositol Triphosphate; Xylityl Phosphate; Zinc Fructose Diphosphate.