Harnessing Gold(I)-Catalyzed Hydroamination/1,3-Sulfonyl Migration Cascade for Divergent Synthesis of Isoxazolidine and Isoxazoline from O-Alkynyl Hydroxylamine

Org Lett. 2024 Aug 2;26(30):6497-6501. doi: 10.1021/acs.orglett.4c02405. Epub 2024 Jul 24.

Abstract

Gold-catalyzed 5-exo-dig hydroamination on O-homopropargylic hydroxylamine gave expeditious access to methylene isoxazolidine. Excess catalyst loading led to facile 1,3-sulfonyl migration in a cascade fashion to furnish the isoxazoline. Mechanistic studies using react-IR and NMR as well as crossover experiments indicated that 1,3-sulfonyl group migration is an intramolecular concerted process. The ene-hydroxylamine moiety also underwent dipolar cycloaddition reactions with nitrile oxide and nitrones leading to the first examples of spirocyclic bis-isoxazolidine derivatives.