Potential SARS-CoV-2 Mpro steroid inhibitors from Aphanamixis polystachya (Wall.) R. N. Parker

Fitoterapia. 2024 Sep:177:106134. doi: 10.1016/j.fitote.2024.106134. Epub 2024 Jul 22.

Abstract

Herein, six previously undescribed steroids (1-6), were isolated from leaves and twigs of Aphanamixis polystachya (Wall.) R. N. Parker (Meliaceae). Their structures were elucidated by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR, UV, and IR. Antiviral activity of these compounds were evaluated. Compounds 1-6 showed varying degrees of inhibitory activity against the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro) at 200 μM.

Keywords: Aphanamixis polystachya; SARS-CoV-2 M(pro); Steroid.

MeSH terms

  • Antiviral Agents* / chemistry
  • Antiviral Agents* / isolation & purification
  • Antiviral Agents* / pharmacology
  • Coronavirus 3C Proteases* / antagonists & inhibitors
  • Humans
  • Meliaceae* / chemistry
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves* / chemistry
  • Plant Stems / chemistry
  • SARS-CoV-2* / drug effects
  • Steroids* / chemistry
  • Steroids* / isolation & purification
  • Steroids* / pharmacology

Substances

  • Antiviral Agents
  • Steroids
  • Coronavirus 3C Proteases
  • 3C-like proteinase, SARS-CoV-2
  • Phytochemicals