Advances in Molecular Research on Hip Joint Impingement-A Vascular Perspective

Biomolecules. 2024 Jun 30;14(7):784. doi: 10.3390/biom14070784.

Abstract

With the rise in longevity within the population, medicine continues to encounter fresh hurdles necessitating prompt actions, among which are those associated with hip joint aging. Age-related arthropathies encompass damage to bones' articulating extremities and their supporting structures, such as articular cartilage, and alterations in the quantity and quality of synovial fluid. This study aims to summarize the biomolecular methods of hip joint evaluation focused on its vascularization, using data correlated with biomolecular research on other joints and tissues, in order to reach an objective opinion of the study prospects in this field. Following a retrospective study on most modern biomolecular research methods on the synovium, the capsule, and the articular cartilage of the hip joint, we have hereby concretized certain future research directions in this field that will improve the qualitative and morphofunctional management of the hip joint at an advanced age, even within population categories at risk of developing various degenerative joint pathologies.

Keywords: cellular senescence; hip joint; joint labrum; vascular endothelial growth factor (VEGF); vasculodegenerative diseases.

Publication types

  • Review

MeSH terms

  • Cartilage, Articular* / metabolism
  • Cartilage, Articular* / pathology
  • Femoracetabular Impingement / pathology
  • Hip Joint* / pathology
  • Humans
  • Synovial Membrane / metabolism
  • Synovial Membrane / pathology

Grants and funding

This research received no external funding.