[Adult-onset immunodeficiency mediated by anti-IFN-γ autoantibody combined with disseminated mycobacterium marseillense infection: a case report]

Zhonghua Nei Ke Za Zhi. 2024 Aug 1;63(8):795-799. doi: 10.3760/cma.j.cn112138-20230816-00061.

[Article in Chinese]

¹ Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Infectious Diseases, Jiujiang No.3 People's Hospital, Jiujiang 332000, China.
² Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
³ Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Abstract

本文报道1例播散性马萨分枝杆菌感染的患者，抗非结核分枝杆菌（NTM）治疗有效，但停药后疗效难以维持；检测其IFN-γ中和性自身抗体阳性。患者最终被诊断为抗IFN-γ自身抗体（AIGA）介导的成人起病免疫缺陷症（AOID）。本文对AOID的临床特点进行描述和讨论，以提高临床对此病的认识。.