Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN): An introduction to the Urinary Urgency Phenotyping Protocol LURN II

Neurourol Urodyn. 2024 Nov;43(8):1800-1808. doi: 10.1002/nau.25566. Epub 2024 Jul 29.

Abstract

Aims: The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is undertaking a new cohort study in LURN II including cases and controls.

Methods: This new cohort was enrolled to specifically study urinary urgency and urgency urinary incontinence, lower urinary tract symptoms (LUTSs) that are often difficult to treat due to a lack of understanding of their phenotypes and pathophysiologies.

Results: This paper will focus on the motivation for the second iteration of LURN and highlight the new research techniques and plans for more thorough phenotyping of this population.

Conclusions: This paper will outline the gaps in understanding in treating LUTSs, specifically urinary urgency.

Keywords: lower urinary tract dysfunction; lower urinary tract symptoms; overactive bladder; phenotyping; urgency urinary incontinence; urinary urgency; voiding.

Publication types

  • Review

MeSH terms

  • Cohort Studies
  • Female
  • Humans
  • Lower Urinary Tract Symptoms* / diagnosis
  • Lower Urinary Tract Symptoms* / physiopathology
  • Male
  • Phenotype*
  • Urinary Incontinence, Urge / diagnosis
  • Urinary Incontinence, Urge / physiopathology