Bio-intelligent plasma-engineered diferuloylmethane/fucoidan/neutrophil lysate/iron oxide nanoclusters for phototherapeutic and magnetotherapeutic with in situ magnetic gelation mitigating inflammatory diseases

Colloids Surf B Biointerfaces. 2024 Nov:243:114054. doi: 10.1016/j.colsurfb.2024.114054. Epub 2024 Jul 4.

Abstract

Creating a versatile and remotely self-assembling biocomposite for delivering therapeutics to alleviate inflammatory diseases poses significant challenges. This study introduces a novel biocomposite, created through cold-atmosphere plasma treatment, that combines fucoidan (Fu) and neutrophil lysate (Nu) to mediate the self-assembly of diferuloylmethane (DIF) and iron oxide (IO) nanoclusters, termed DIF-Nu/Fu-IO NC. This biocomposite forms a phototherapeutic and magnetically-driven in situ gel with open-porous architecture loaded with DIF, offering non-invasive theranostic capabilities for treating inflammatory diseases. It demonstrates efficacy in both an intraarticular zymosan-induced rheumatoid arthritis animal model and an intranasal LPS-induced inflammatory lung model. Upon administration, near-infrared (NIR) irradiation and magnet application significantly improved the condition of the animals with rheumatoid arthritis and lung inflammation. This breakthrough heralds a new paradigm in bioinspired, versatile, theranostic, self-assembling biocomposites for addressing clinical inflammatory diseases.

Keywords: Inflammatory diseases; Magnetic-driven in situ gelation; Non-invasive theranostics; Phototherapeutic.

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / pathology
  • Arthritis, Rheumatoid / therapy
  • Ferric Compounds / chemistry
  • Furocoumarins / chemistry
  • Furocoumarins / pharmacology
  • Gels / chemistry
  • Humans
  • Inflammation / drug therapy
  • Mice
  • Neutrophils* / drug effects
  • Neutrophils* / metabolism
  • Particle Size
  • Phototherapy / methods
  • Plasma Gases / chemistry
  • Polysaccharides* / chemistry
  • Surface Properties

Substances

  • Polysaccharides
  • fucoidan
  • ferric oxide
  • Ferric Compounds
  • Furocoumarins
  • Plasma Gases
  • Gels