A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH

Affiliations

• ¹ Department of General Surgery, Cancer Center, Peking University Third Hospital, Beijing, China; Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China.
• ² Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Peking University, Beijing, China.
• ³ Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Peking University, Beijing, China; Department of Endocrinology, Capital Medical University Chaoyang Hospital, Beijing, China.
• ⁴ Department of Endocrinology, Capital Medical University Chaoyang Hospital, Beijing, China.
• ⁵ Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China; State Key Laboratory of Female Fertility Preservation, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
• ⁶ Mengniu Institute of Nutrition Science, Shanghai, China.
• ⁷ Mengniu Institute of Nutrition Science, Shanghai, China; Shanghai Institute of Nutrition and Health, The Chinese Academy of Sciences, Shanghai, China.
• ⁸ National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
• ⁹ Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China.
• ¹⁰ Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China; Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
• ¹¹ Department of Endocrinology, Capital Medical University Chaoyang Hospital, Beijing, China. Electronic address: [email protected].
• ¹² Department of General Surgery, Cancer Center, Peking University Third Hospital, Beijing, China; Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China. Electronic address: [email protected].
• ¹³ Department of General Surgery, Cancer Center, Peking University Third Hospital, Beijing, China; Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China. Electronic address: [email protected].
• ¹⁴ Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Peking University, Beijing, China; Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Peking University, Beijing, China; NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China. Electronic address: [email protected].
• ¹⁵ State Key Laboratory of Female Fertility Preservation, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. Electronic address: [email protected].