Paradoxical Reaction during Treatment of Tuberculous Meningoencephalitis in a Patient with Systemic Lupus Erythematosus

Isadora Lemos Versiani; Gabriela Flor Nimer; Carolina Braga Moura; Arthur Ferreira Xavier; Rodrigo Cutrim Gaudio; Fernanda Cristina Rueda Lopes; Caroline Bittar Braune

doi:10.4103/jgid.jgid_96_23

Paradoxical Reaction during Treatment of Tuberculous Meningoencephalitis in a Patient with Systemic Lupus Erythematosus

J Glob Infect Dis. 2024 Jun 26;16(2):73-75. doi: 10.4103/jgid.jgid_96_23. eCollection 2024 Apr-Jun.

Authors

Isadora Lemos Versiani¹, Gabriela Flor Nimer¹, Carolina Braga Moura¹, Arthur Ferreira Xavier¹, Rodrigo Cutrim Gaudio², Fernanda Cristina Rueda Lopes³, Caroline Bittar Braune⁴

Affiliations

¹ Department of Neurology, University Hospital Antonio Pedro, Fluminense Federal University, Niteroi, Brazil.
² Department of Rheumatology, University Hospital Antonio Pedro, Fluminense Federal University, Niteroi, Brazil.
³ Department of Radiology, University Hospital Antonio Pedro, Fluminense Federal University and DASA Group, Niteroi, Brazil.
⁴ Department of Neurology, University Hospital Antonio Pedro, Fluminense Federal University and University Hospital Gaffrée and Guinle/State of Rio de Janeiro Federal University, Niterói, Brazil and Rio de Janeiro, Brazil.

Abstract

Tuberculous paradoxical reaction presents as clinical deterioration during appropriate tuberculosis therapy and is a separate entity from treatment failure and drug resistance. We describe a case of central nervous system paradoxical reaction following tuberculous meningoencephalitis treatment in an immunocompromised patient with systemic lupus erythematosus.

Keywords: Central nervous system; lupus erythematosus; systemic; tuberculosis.

Publication types

Case Reports