Objective: To explore the association between obesity/overweight and the risk of malignancy in Hürthle cell neoplasms of the thyroid. Methods: The data of patients with complete data who were diagnosed with Hürthle cell neoplasms of the thyroid at the Third Hospital of Peking University from September 2016 to September 2023 were retrospectively collected. Based on postoperative pathological diagnosis, tumors were classified into thyroid Hürthle cell adenoma group and Hürthle cell carcinoma group. Multivariate logistic regression analysis was employed to explore the association between overweight/obesity and the risk of malignancy in Hürthle cell neoplasms of the thyroid. Results: A total of 102 patients (13 males and 89 females) were included, aged (48.7±13.1) years. There were 22 cases of thyroid Hürthle cell carcinoma and 80 cases of thyroid Hürthle cell adenoma. Univariate analysis showed that the rate of overweight/obesity in the Hürthle cell carcinoma group was higher than that in the adenoma group [73% (16/22) vs 46% (37/80), P=0.050]. Multivariate logistic regression analysis indicated that the overweight/obese patients had a higher risk of malignancy in Hürthle cell neoplasms of the thyroid compared with the non-overweight/obese patients (OR=3.170, 95%CI: 1.126-9.955, P=0.035). Sensitivity analysis excluding individuals with multiple tumors was consistent with the main study results (OR=2.878, 95%CI: 0.922-10.228, P=0.080). Conclusion: Overweight/obesity may be associated with a higher risk of malignancy in patients with Hürthle cell neoplasms of the thyroid.
目的： 探讨超重肥胖与甲状腺嗜酸性细胞肿瘤恶性风险的关联。 方法： 回顾性收集2016年9月至2023年9月北京大学第三医院甲状腺嗜酸性细胞肿瘤患者的临床资料，根据术后病理诊断分为甲状腺嗜酸性细胞腺瘤组和嗜酸性细胞癌组。采用多因素logistic回归分析超重肥胖与甲状腺嗜酸性细胞肿瘤恶性风险的关联。 结果： 共纳入102例患者，男13例，女89例，年龄（48.7±13.1）岁，甲状腺嗜酸性细胞癌22例，甲状腺嗜酸性细胞腺瘤80例。单因素分析结果显示，甲状腺嗜酸性细胞癌组的超重肥胖率高于嗜酸性细胞腺瘤组［73%（16/22）比46%（37/80），P=0.050］。多因素logistic回归分析结果显示，与非超重肥胖患者相比，超重肥胖患者具有更高的甲状腺嗜酸性细胞肿瘤恶性风险（OR=3.170，95%CI：1.126~9.955，P=0.035）。剔除多发肿瘤个体后进行的敏感性分析与主要研究结果方向一致（OR=2.878，95%CI：0.922~10.228，P=0.080）。 结论： 在甲状腺嗜酸性细胞肿瘤患者中，超重肥胖可能与更高的肿瘤恶性风险有关。.