Antimycotic 2-alkyldithio, 2-aralkyldithio, 2-aryldithiobenzamides

Farmaco Sci. 1985 Nov;40(11):803-7.

Abstract

Some 2-alkyldithio, 2-aralkyldithio, 2-aryldithio benzoic acids, their methyl esters and N-monosubstituted amides were prepared and tested in vitro against Candida albicans and Trichophyton mentagrophytes. Some N-monosubstituted amides displayed activities similar to those of clotrimazole and pyrrolnitrin. Against Candida albicans, N-monosubstituted amides exhibited a generally higher activity than the corresponding N-monosubstituted amides of 2,2'-dicarboxydiphenyldisulfide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemical synthesis*
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology
  • Candida albicans / drug effects
  • Microbial Sensitivity Tests
  • Structure-Activity Relationship
  • Thioamides / chemical synthesis*
  • Thioamides / pharmacology
  • Trichophyton / drug effects

Substances

  • Amides
  • Antifungal Agents
  • Thioamides