Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201

Affiliations

• ¹ Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital; South Australia Health and Medical Research Institute; South Australia ImmunoGENomics Cancer Institute, University of Adelaide, Adelaide, Australia.
• ² The Anticancer Fund, Meise, Belgium.
• ³ Developmental and Stem Cell Biology, Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
• ⁴ Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
• ⁵ Departments of Medical Biophysics and Pediatrics, University of Toronto, Toronto, ON, Canada.
• ⁶ Department of Pediatrics, McGill University, RI-MUHC, Montreal, QC, Canada.
• ⁷ Children's National Hospital, Washington, DC.
• ⁸ Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute, Melbourne, VIC, Australia.
• ⁹ Department of Pediatric and Adolescent Oncology and Hematology, Perth Children's Hospital; Telethon Kid's Cancer Centre, Telethon Kid's Institute, University of Western Australia, Perth, WA, Australia.
• ¹⁰ St Jude Children's Research Hospital, Memphis, TN.
• ¹¹ Stanford University, Palo Alto, CA.
• ¹² Colorado Children's Hospital, Denver, CO.
• ¹³ Preston Robert Tisch Brain Tumor Centre, Duke University, Durham, NC.
• ¹⁴ Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.
• ¹⁵ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, NSW, Australia.
• ¹⁶ Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.
• ¹⁷ Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute; Department of Pediatrics, University of Melbourne, Melbourne, VIC, Australia.
• ¹⁸ Pediatric Oncology Unit, Fondazione IRCCS Instituto Nazionale dei Tumori, Milan, Italy.
• ¹⁹ Hopp Children's Cancer Centre Heidelberg (KiTZ), Heidelberg, Germany.
• ²⁰ Department of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer 36 Consortium (DKTK), Heidelberg, Germany.
• ²¹ Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.
• ²² National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
• ²³ University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• ²⁴ UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
• ²⁵ Department of Neuro-Oncology, Nationwide Children's Hospital, Columbus, OH.
• ²⁶ The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.