Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers

Jessica M Logan; Carmela Martini; Alexandra Sorvina; Ian R D Johnson; Robert D Brooks; Maria C Caruso; Chelsea Huzzell; Courtney R Moore; Litsa Karageorgos; Lisa M Butler; Prerna Tewari; Sarita Prabhakaran; Shane M Hickey; Sonja Klebe; Hemamali Samaratunga; Brett Delahunt; Kim Moretti; John J O'Leary; Douglas A Brooks; Ben S-Y Ung

doi:10.1038/s41597-024-03696-0

Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers

Sci Data. 2024 Aug 8;11(1):852. doi: 10.1038/s41597-024-03696-0.

Authors

Jessica M Logan^#¹, Carmela Martini^#², Alexandra Sorvina^#³, Ian R D Johnson², Robert D Brooks², Maria C Caruso², Chelsea Huzzell², Courtney R Moore², Litsa Karageorgos², Lisa M Butler^{4

5}, Prerna Tewari⁶, Sarita Prabhakaran⁷, Shane M Hickey², Sonja Klebe⁷, Hemamali Samaratunga⁸, Brett Delahunt⁹, Kim Moretti^{10

11

12}, John J O'Leary⁶, Douglas A Brooks², Ben S-Y Ung^{2

13}

Affiliations

¹ Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia. [email protected].
² Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
³ Centre for Cancer Biology, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia.
⁴ South Australian ImmunoGENomics Cancer Institute and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5005, Australia.
⁵ Solid Tumour Program, Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
⁶ Department of Histopathology, Trinity College Dublin, D02 PN40, Dublin, Ireland.
⁷ Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
⁸ Aquesta Uropathology, The University of Queensland, Brisbane, QLD, 4072, Australia.
⁹ Malaghan Institute of Medical Research, Wellington, 6012, New Zealand.
¹⁰ Discipline of Surgery, University of Adelaide, Adelaide, SA, 5371, Australia.
¹¹ Allied Health and Human Performance, University of South Australia, Adelaide, SA, 5005, Australia.
¹² Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, 3800, Australia.
¹³ Quality Use of Medicines and Pharmacy Research Centre, University of South Australia City East Campus, Frome Rd, Adelaide, SA, 5000, Australia.

^# Contributed equally.

Abstract

The diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the assessment of Haematoxylin and Eosin (H&E) staining, which can be difficult to interpret and introduce inter-observer variability. Here, we present a digital pathology atlas and online resource of prostate cancer tissue micrographs for both H&E and the reinterpretation of samples using a novel set of three biomarkers as an interactive tool, where clinicians and scientists can explore high resolution histopathology from various case studies. The digital pathology prostate cancer atlas when used in conjunction with the biomarkers, will assist pathologists to accurately grade prostate cancer tissue samples.

Publication types

Dataset

MeSH terms

Adaptor Proteins, Signal Transducing*
Adaptor Proteins, Vesicular Transport*
Biomarkers, Tumor*
Humans
Male
Prostatic Neoplasms* / pathology
Syndecan-1* / analysis

Substances

Biomarkers, Tumor
Syndecan-1
Adaptor Proteins, Vesicular Transport
sortilin
Adaptor Proteins, Signal Transducing

Grants and funding

GNT1092904/Department of Health | National Health and Medical Research Council (NHMRC)