A Case of Immunoglobulin G4-Related Gastrointestinal Disease Diagnosed From Persistent Diarrhea and Abdominal Pain

Takehiro Hirano; Yujiro Kawakami; Sayaka Nakabayashi; Kohei Wagatsuma; Keisuke Ishigami; Yoshiharu Masaki; Ayako Murota; Masatoshi Kanda; Shintaro Sugita; Kenji Notohara; Hiroshi Nakase

doi:10.1016/j.gastha.2023.07.009

A Case of Immunoglobulin G4-Related Gastrointestinal Disease Diagnosed From Persistent Diarrhea and Abdominal Pain

Gastro Hep Adv. 2023 Jul 21;2(8):1089-1092. doi: 10.1016/j.gastha.2023.07.009. eCollection 2023.

Affiliations

¹ Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
² Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
³ Department of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
⁴ Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
⁵ Department of Anatomic Pathology, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disease characterized by the infiltration of IgG4-positive plasma cells and fibrosis in organs throughout the body. IgG4-RD involvement in the gastrointestinal (GI) tract (IgG4-related GI disease; IgG4-GID) is rare, and the disease concept remains unclear. Generally, IgG4-GID has been reported with morphological changes, including ulcers, strictures, and submucosal tumors. Here, we report a case of IgG4-GID with persistent diarrhea and abdominal pain in which typical endoscopic findings were absent. This case suggests the unidentified clinical features of IgG4-GID.

Keywords: Abdominal Pain; Diarrhea; IgG4-Related Dacryoadenitis and Sialadenitis; IgG4-Related Disease; IgG4-Related Gastrointestinal Disease; Inflammatory Disease.

Publication types

Case Reports