In this systematic review, we synthesized evidence on benefits and harms of XR interventions for treatment of chronic pain or to prevent development of chronic pain (if treating acute pain). We present findings by pain condition, beginning with chronic low back pain and chronic neck pain, followed by other conditions. Within each condition, we provide results separately for VR and AR interventions, and then types of XR interventions (and comparators) within these categories. We conducted meta-analyses where feasible and provide qualitative summaries otherwise.