Linear mechanical systems with time-modulated parameters can harbor oscillations with amplitudes that grow or decay exponentially with time due to the phenomenon of parametric resonance. While the resonance properties of individual oscillators are well understood, those of systems of coupled oscillators remain challenging to characterize. Here we determine the parametric resonance conditions for time-modulated mechanical systems by exploiting the internal symmetries arising from the real-valued and symplectic nature of classical mechanics. We also determine how these conditions are further constrained when the system exhibits external symmetries. In particular, we analyze systems with space-time symmetry where the system remains invariant after a combination of discrete translation in both space and time. For such systems, we identify a combined space-time translation operator that provides more information about the dynamics of the system than the Floquet operator does and use it to derive conditions for one-way amplification of traveling waves. Our exact theoretical framework based on symmetries enables the design of exotic responses such as nonreciprocal transport and one-way amplification in dynamic mechanical metamaterials and is generalizable to all physical systems that obey space-time symmetry.