The ability of olfaction to distinguish odors is based on many different properties deriving from the molecular structure, including chirality. Even if the electronic nose (e-nose) concept has been widely used in strict analogy with biological systems to implement sensor arrays that recognize and distinguish complex odor matrices, the fabrication of an enantioselective e-nose remains a challenge. This paper introduces an array of quartz microbalances (QMB) functionalized with sensitive materials made of a combination of achiral receptors and silica nanohelices grafted by chiral and achiral porphyrins. In this combination, nanohelices provide a chiral template for the spatial arrangement of porphyrins, while porphyrins act as receptors that can interact differently with analytes. Remarkably, even if single sensors show scarce enantioselectivity, the signals of the overall array achieve recognition of the chiral identity of the five diverse enantiomeric pairs tested when the data are processed with proper multivariate algorithms. Such an innovative and generalizable approach is expected to enable the formation of an extensive library of readily integrable chiral receptors in enantioselective sensor arrays, potentially revolutionizing diverse fields such as agrochemicals, medicine, and environmental sciences.
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